NLRP7: From Inflammasome Regulation to Human Disease
نویسندگان
چکیده
منابع مشابه
NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.
Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists...
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Cytosolic pathogen- and damage-associated molecular patterns are sensed by pattern recognition receptors, including members of the nucleotide-binding domain and leucine-rich repeat-containing gene family (NLR), which cause inflammasome assembly and caspase-1 activation to promote maturation and release of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18 and induction of pyroptosis. H...
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ژورنال
عنوان ژورنال: Immunology
سال: 2021
ISSN: 0019-2805,1365-2567
DOI: 10.1111/imm.13372